Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits

E. Ortolani; M. Guerriero; A. Coli; A. Di Giannuario; G. Minniti; A. Polimeni

doi:10.59987/ads/2014.2.66-68

Vol. 5 No. 2 (2014)

DOI: 10.59987/ads/2014.2.66-68

Original Article

2022-08-16

Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits

E. Ortolani , M. Guerriero , A. Coli, A. Di Giannuario, G. Minniti , A. Polimeni

Keywords: PDGF, IGF-1, PRP, growth factors, bone formation, dental implants

Abstract

The ability of platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and platelet-rich plasma (PRP) to increase the rate of osseointegration of endosseous implants and to improve the quality of bone remodeling on the surface of titanium, has been investigated in an experimental intraosseous defect model by an histological and immunohistochemical evaluation. The results from this study demonstrate that rabbits treated with the combination PDGF/IGF-1 showed a higher positive effect on bone regeneration than PRP-treated or controls.

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Authors

E. Ortolani

M. Guerriero

A. Coli

A. Di Giannuario

G. Minniti

A. Polimeni

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Authors contributing to Annali di Stomatologia agree to publish their articles under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows third parties to copy and redistribute the material providing appropriate credit and a link to the license but does not allow to use the material for commercial purposes and to use the material if it has been remixed, transformed or built upon.

How to Cite

Ortolani , E., Guerriero , M., Coli, A., Di Giannuario, A., Minniti , G., & Polimeni , A. (2022). Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits. Annali Di Stomatologia, 5(2), 66–68. https://doi.org/10.59987/ads/2014.2.66-68

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